Clone:
REA233
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL21R, NILR

Specifications for CD360 (IL-21R) Antibody, anti-human, REAfinity™

Overview

Clone REA233 recognizes CD360, which is also known as interleukin 21 (IL-21) receptor. CD360 forms a heterodimer with the common γ subunit, which is shared by other receptors such as IL-2 and IL-15 receptor and serves as the receptor for IL-21. CD360 is a single-pass type I membrane protein and belongs to the type I cytokine receptor family. Expression of CD360 is found on variety of cells including B cells, NK cells subsets, T cells, NKT cells, dendritic cells, macrophages, and non-hematopoietic cells such as keratinocytes and fibroblasts. CD360 is composed of the cytokine-binding domain, a transmembrane domain and a large intracellular domain that contains conserved structural motifs, including the commonly described box 1 and box 2 elements, which are important for signal transduction. IL-21 mediated signaling plays vital role in mediating immune response and is involved in enhancement of adaptive T cell–immunity, antibody production, activation of natural killer cell subtypes, and opposing the suppressive effects mediated by regulatory T cells.
Additional information: Clone REA233 displays negligible binding to Fc receptors.

Alternative names

IL21R, NILR

Detailed product information

Technical specifications

CloneREA233
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD360 (IL-21R)
Alternative names of antigenIL21R, NILR
Distribution of antigenB cells, dendritic cells, NK cells, T cells
RRIDAB_2657744, AB_2657745, AB_2657746, AB_2657747, AB_2657748, AB_2657749, AB_2657750, AB_2657751

References for CD360 (IL-21R) Antibody, anti-human, REAfinity™

Publications

  1. Lowe, L. et al. (2011) IL-21R is critical for the development of memory responses. J. Immunol. 186: 150
  2. Hamming, O. J. et al. (2012) Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. J. Biol. Chem. 287: 9454-9460

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