Clone:
REA394
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IHC, IF
Alternative names:
SLAMF8, BLAME, SBBI42

Specifications for CD353 (SLAMF8) Antibody, anti-human, REAfinity™

Overview

Clone REA394 recognizes the human CD353 antigen, a single-pass type I membrane protein, which is also known as SLAM family member 8 (SLAMF8) or B-lymphocyte activator macrophage (BLAME). CD353 is an immunoglobulin superfamily protein that is a member of the SLAM/CD150/CD2 family of receptors. It is expressed in lymphoid tissue and, more specifically, in some populations of professional APCs, activated monocytes, DCs, and upon activation of macrophages by interferon gamma (IFN-γ) or bacteria. CD353 may play a role in B lineage commitment and/or modulation of signal through the B cell receptor.
Additional information: Clone REA394 displays negligible binding to Fc receptors.

Alternative names

SLAMF8, BLAME, SBBI42

Detailed product information

Technical specifications

CloneREA394
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD353 (SLAMF8)
Alternative names of antigenSLAMF8, BLAME, SBBI42
Molecular mass of antigen [kDa]29
Distribution of antigendendritic cells, monocytes
Entrez Gene ID56833
RRIDAB_2657690, AB_2657691, AB_2657692, AB_2657693, AB_2657694, AB_2657695

References for CD353 (SLAMF8) Antibody, anti-human, REAfinity™

Publications

  1. Kingsbury, G. A. et al. (2001) Cloning, expression, and function of BLAME, a novel member of the CD2 Family. J. Immunol. 166(9): 5675-5680
  2. Wang, G. et al. (2012) Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages. J. Immunol. 188(12): 5829-5832
  3. Matesanz-Isabel, J. et al. (2011) New B-cell CD molecules. Immunol. Lett. 134(2): 104-112

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