Clone:
REA1096
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Fz-4, hFz4, FzE4, FZD4, Fz4, GPCR

Specifications for CD344 (Frizzled-4) Antibody, anti-human, REAfinity™

Overview

Clone REA1096 recognizes an extracellular epitope of the human CD344 antigen, a multi-pass membrane protein which is also known as Frizzled family receptor 4 (FZD4) or Frizzled-4. CD344 is expressed by neuronal stem cells and also found on fetal neuronal progenitor cells and neuronal intestinal cells. It is a member of the Frizzled family of proteins which encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. CD344 is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). It is the only representative of frizzled family members that binds strongly an additional ligand Norrin that is functionally similar but structurally different from Wingless type proteins. CD344 signaling induced by Norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear.
Additional information: Clone REA1096 displays negligible binding to Fc receptors.

Alternative names

Fz-4, hFz4, FzE4, FZD4, Fz4, GPCR

Detailed product information

Technical specifications

CloneREA1096
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD344 (Frizzled-4)
Alternative names of antigenFz-4, hFz4, FzE4, FZD4, Fz4, GPCR
Molecular mass of antigen [kDa]56
Distribution of antigenneuronal intestinal cells, fetal neuronal progenitor cells, neural stem cells
Entrez Gene ID8322
RRIDAB_2733736, AB_2733737, AB_2733318, AB_2733319, AB_2732942, AB_2732943, AB_2733188, AB_2733189, AB_2733019, AB_2733020, AB_2733992, AB_2733993, AB_2733481, AB_2733482

References for CD344 (Frizzled-4) Antibody, anti-human, REAfinity™

Publications

  1. Kirikoshi, H. et al. (1999) Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. Biochem. Biophys. Res. Commun. 264(3): 955-961
  2. Ye, X. et al. (2009) Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 139(2): 285-298
  3. Descamps, B. et al. (2012) Frizzled 4 regulates arterial network organization through noncanonical Wnt/planar cell polarity signaling. Circ. Res. 110(1): 47-58

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