Clone:
CH3A4A7
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
FZD4, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4

Specifications for CD344 (Frizzled-4) Antibody, anti-human

Overview

Clone CH3A4A7 recognizes an extracellular epitope of the human CD344 antigen, a multi-pass membrane protein which is also known as Frizzled family receptor 4 (FZD4) or Frizzled-4. CD344 is expressed by neuronal stem cells and also found on fetal neuronal progenitor cells and neuronal intestinal cells. It is a member of the Frizzled family of proteins which encode seven-transmembrane domain proteins that are receptors for the wingless-type MMTV integration site family of signaling proteins. CD344 is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). It is the only representative of frizzled family members that binds strongly an additional ligand norrin that is functionally similar but structurally different from wingless-type proteins. CD344 signaling induced by norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear.

Alternative names

FZD4, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4

Detailed product information

Technical specifications

CloneCH3A4A7
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD344 (Frizzled-4)
Alternative names of antigenFZD4, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4
Molecular mass of antigen [kDa]56
Distribution of antigenstem cells, neural stem cells
Entrez Gene ID8322
RRIDAB_2657645, AB_2657646, AB_2657647, AB_2657648, AB_2657649, AB_2657650, AB_2657651, AB_2657644

References for CD344 (Frizzled-4) Antibody, anti-human

Publications

  1. Kirikoshi, H. et al. (1999) Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. Biochem. Biophys. Res. Commun. 264(3): 955-961
  2. Ye, X. et al. (2009) Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 139(2): 285-298
  3. Descamps, B. et al. (2012) Frizzled 4 regulates arterial network organization through noncanonical Wnt/planar cell polarity signaling. Circ. Res. 110(1): 47-58

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