Clone:
2.29
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1
Applications:
FC
Alternative names:
NCR2, LY95, NKp44

Specifications for CD336 (NKp44) Antibody, anti-human

Overview

Clone 2.29 recognizes the CD336 antigen, also known as NKp44. CD336 is a member of the natural cytotoxicity receptor (NCR) family which trigger cytotoxicity in natural killer (NK) cells. CD336 is directly involved in target cell recognition and lysis and is only expressed by activated NK cells, e.g., NK cells cultured in the presence of interleukin 2 (IL-2). Freshly isolated, resting NK cells do not express CD336 (Nkp44).

Alternative names

NCR2, LY95, NKp44

Detailed product information

Technical specifications

Clone2.29
Clonalitymonoclonal
Isotypemouse IgG1
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD336 (NKp44)
Alternative names of antigenNCR2, LY95, NKp44
Molecular mass of antigen [kDa]28
Distribution of antigenNK cells, thymic epithelial cells
Entrez Gene ID9436
RRIDAB_2734066, AB_2752163, AB_2752113, AB_2811349, AB_2811336, AB_2752164, AB_2752114, AB_2752162, AB_2752112, AB_615083, AB_2734065

References for CD336 (NKp44) Antibody, anti-human

Publications

  1. Vitale, M. et al. (1998) NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J. Exp. Med. 187: 2065-2072
  2. Moretta, L. and Moretta, A. (2004) Unravelling natural killer function: Triggering and inhibitory human NK receptors. EMBO J. 23: 255-259
  3. Sivori, S. et al. (2000) 2B4 functions as a co-receptor in human NK cell activation. Eur. J. Immunol. 30: 787-793
  4. Moretta, A. et al. (2001) Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19: 197-223
  5. Chaput, N. et al. (2013)
    Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR
    +
    NK cell levels correlate with disease outcome.
    Oncoimmunology 2(2): e23080

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