Clone:
REA852
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CD33 antigen-like 1, CDw327, Obesity-binding protein 1, Siglec-6

Specifications for CD327 (Siglec-6) Antibody, anti-human, REAfinity™

Overview

Clone REA852 recognizes the human CD327 antigen, which is also known as sialic acid binding Ig-like lectin 6 (Siglec-6), belonging to the Ig superfamily that is involved in cell-cell interactions and signaling. As an adhesion molecule, CD327 mediates sialic acid dependent interaction to cells by binding to the alpha-2,6-linked sialic acid and is highly expressed in placenta and at low levels in spleen, peripheral blood leukocytes, and small intestine.
Additional information: Clone REA852 displays negligible binding to Fc receptors.

Alternative names

CD33 antigen-like 1, CDw327, Obesity-binding protein 1, Siglec-6

Detailed product information

Technical specifications

CloneREA852
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD327 (Siglec-6)
Alternative names of antigenCD33 antigen-like 1, CDw327, Obesity-binding protein 1, Siglec-6
Molecular mass of antigen [kDa]47
Distribution of antigenleukocytes, spleen, placenta
Entrez Gene ID946
RRIDAB_2725882, AB_2725906, AB_2725883, AB_2725907, AB_2725884, AB_2725904, AB_2725881, AB_2725905

References for CD327 (Siglec-6) Antibody, anti-human, REAfinity™

Publications

  1. Powell, L. D. et al. (1995) I-type lectins. J. Biol. Chem. 270(24): 14243-14246
  2. Patel, N. et al. (1999) OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. J. Biol. Chem. 274(32): 22729-22738
  3. Crocker, P. R. et al. (2002) New I-type lectins of the CD 33-related siglec subgroup identified through genomics. Biochem. Soc. Symp. (69): 83-94

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