Clone:
REA811
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin, Cadherin-1

Specifications for CD324 (E-Cadherin) Antibody, anti-human, REAfinity™

Overview

Clone REA811 recognizes CD324, also known as E-cadherin or cadherin-1, which is a calcium-dependent cell adhesion protein found in adherence junctions of epithelial cells, e.g., in colon, uterus, liver, keratinocytes, etc. E-cadherin also serves as a ligand for integrin α-E/β-7. The epitope is expressed by a variety of carcinoma-derived cell lines such as MCF-7, HT-29, T-47D, NTERA-2, and 2102Ep. Loss of E-cadherin is thought to enable metastasis by disrupting intercellular contacts – an early step in metastatic dissemination. Furthermore, E-cadherin is a marker of undifferentiated embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. For these cells, E-cadherin plays a major role in conveying cell survival signals.
Additional information: Clone REA811 displays negligible binding to Fc receptors

Alternative names

CDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin, Cadherin-1

Detailed product information

Technical specifications

CloneREA811
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD324 (E-Cadherin)
Alternative names of antigenCDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin, Cadherin-1
Molecular mass of antigen [kDa]80
Distribution of antigenendothelial cells, ES and iPS cells
Entrez Gene ID999
RRIDAB_2657481, AB_2657482, AB_2657483, AB_2657484, AB_2657485, AB_2657486, AB_2657487, AB_2657488, AB_2657489, AB_2657490, AB_2657491, AB_2857787, AB_2857786, AB_2657480

References for CD324 (E-Cadherin) Antibody, anti-human, REAfinity™

Publications

  1. Onder, T. T. et al. (2008) Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 68: 3645-3654
  2. Eastham, A. M. et al. (2007) Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res. 67: 11254-11262
  3. Higgins, J. M. et al. (1998) Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin. J. Cell Biol. 140: 197-210
  4. Li, Z. et al. (2010) Spatially resolved quantification of E-cadherin on target hES cells. J. Phys. Chem. B 114: 2894-2900

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