Clone:
67A4
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
CDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin

Specifications for CD324 (E-Cadherin) Antibody, anti-human

Overview

CD324, also known as E-Cadherin or cadherin-1, is a calcium-dependent cell adhesion protein found in adherence junctions of epithelial cells, e.g., in colon, uterus, liver, keratinocytes, etc. CD324 also serves as a ligand for integrin alpha-E/beta-7. The epitope is expressed by a variety of carcinoma-derived cell lines such as MCF-7, HT-29, T-47D, NTERA-2, and 2102Ep. Loss of CD324 is thought to enable metastasis by disrupting intercellular contacts – an early step in metastatic dissemination. Furthermore, CD324 is a marker of undifferentiated embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. For these cells, CD324 plays a major role in conveying cell survival signals.

Alternative names

CDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin

Detailed product information

Technical specifications

Clone67A4
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD324 (E-Cadherin)
Alternative names of antigenCDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin
Molecular mass of antigen [kDa]80
Distribution of antigenepithelial cells, platelets, stem cells, ES and iPS cells
Entrez Gene ID999
RRIDAB_10827695, AB_2660959, AB_10828796, AB_2660960, AB_2660961, AB_2660962, AB_2660963, AB_2660958

Resources for CD324 (E-Cadherin) Antibody, anti-human

Documents and Protocols

References for CD324 (E-Cadherin) Antibody, anti-human

Publications

  1. Xu, Y. et al. (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. U.S.A. 107(18): 5129-8134
  2. Onder, T. T. et al. (2008) Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 68: 3645-3654
  3. Eastham, A. M. et al. (2007) Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res. 67: 11254-11262
  4. Higgins, J. M. et al. (1998) Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin. J. Cell Biol. 140: 197-210
  5. Li, Z. et al. (2010) Spatially resolved quantification of E-cadherin on target hES cells. J. Phys. Chem. B 114: 2894-2900

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