Clone:
REA429
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
JAM-3, JAM-C, JAM-2

Specifications for CD323 (JAM3) Antibody, anti-human, REAfinity™

Overview

Clone REA429 recognizes the human CD323 antigen, a single-pass type I membrane protein, which is also known as junctional adhesion molecule 3 (JAM3) or JAM-C. CD323 is a member of the junctional adhesion molecule family and plays a role in leukocyte migration and cell-cell adhesion. CD323 expression is found on endothelial cells and human platelets. It is expressed at desmosomes but not at tight junctions. CD323 is also expressed at low levels on T cells and is upregulated upon activation.
Additional information: Clone REA429 displays negligible binding to Fc receptors.

Alternative names

JAM-3, JAM-C, JAM-2

Detailed product information

Technical specifications

CloneREA429
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD323 (JAM3)
Alternative names of antigenJAM-3, JAM-C, JAM-2
Molecular mass of antigen [kDa]31
Distribution of antigenendothelial cells, T cells, platelets
Entrez Gene ID83700
RRIDAB_2657469, AB_2657470, AB_2657471, AB_2657472, AB_2657473, AB_2657474, AB_2657475, AB_2657476, AB_2657477, AB_2657478, AB_2657479, AB_2657468

References for CD323 (JAM3) Antibody, anti-human, REAfinity™

Publications

  1. Arrate, M. P. et al. (2001) Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. J. Biol. Chem. 276(49): 45826-45832
  2. Cunningham, S. A. et al. (2002) JAM2 interacts with alpha4beta1. Facilitation by JAM3. J. Biol. Chem. 277(31): 27589-27592
  3. Mochida, G. H. et al. (2010) A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Am. J. Hum. Genet. 87(6): 882-889

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