Clone:
REA471
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Klrk1, Nkg2d, NKLLR, NKR-P2, NKG2D

Specifications for CD314 (NKG2D) Antibody, anti-rat, REAfinity™

Overview

Clone REA471 recognizes the rat CD314 antigen, a single-pass type II membrane homodimeric glycoprotein belonging to the C-type lectin-like receptor family, which is also known as NKG2-D type II integral membrane protein (NKG2D) or killer cell lectin-like receptor subfamily K member 1 (Klrk1). Rat CD314 is expressed in NK cells, and is strongly expressed in resting CD8
+
and CD4
+
T cells, but not by thymocytes or other hemopoietic cells. It functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. CD314 provides both, stimulatory and costimulatory innate immune responses on activated killer cells, leading to cytotoxic activity. It acts as a costimulatory receptor for T cell–receptor in CD8
+
T cell–mediated adaptive immune responses by amplifying T cell–activation. Ligands of CD314 belong to various subfamilies of MHC class I–related glycoproteins.
Additional information: Clone REA471 displays negligible binding to Fc receptors.

Alternative names

Klrk1, Nkg2d, NKLLR, NKR-P2, NKG2D

Detailed product information

Technical specifications

CloneREA471
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD314 (NKG2D)
Alternative names of antigenKlrk1, Nkg2d, NKLLR, NKR-P2, NKG2D
Molecular mass of antigen [kDa]24
Distribution of antigenNK cells, T cells
Entrez Gene ID24934
RRIDAB_2657356, AB_2657357, AB_2657358, AB_2657359, AB_2657360, AB_2657361, AB_2657362, AB_2657355

References for CD314 (NKG2D) Antibody, anti-rat, REAfinity™

Publications

  1. Berg, S. F. et al. (1998) Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells. Int. Immunol. 10(4): 379-385
  2. Flornes, L. M. et al. (2010) The complete inventory of receptors encoded by the rat natural killer cell gene complex. Immunogenetics 62(8): 521-530
  3. Lai, C. B. et al. (2009) Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion. Nucleic Acids Res. 37(9): 3032-3043

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