Clone:
REA1175
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Klrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d

Specifications for CD314 (NKG2D) Antibody, anti-mouse, REAfinity™

Overview

Clone REA1175 recognizes the mouse CD314 (NKG2D), a type II transmembrane homodimeric glycoprotein belonging to the C-type lectin-like receptor family. CD314 in mice is expressed on activated CD8
+
αβ T cells, NK cells, subsets of γδ T cells, IFN-producing killer dendritic cells, subsets of NKT cells, and activated macrophages. For signaling, CD314 associates with signaling adapters DAP10 and DAP12 and transduces signal via the PI3-kinase pathway and the Syk-Zap70 pathways, respectively. CD314 recognizes multiple ligands, which are either uregulated in response to cellular stresses such as heat shock, infection, and DNA damage or are constitutively expressed, such as on tumor cells. Known ligands of CD314 in mice include murine UL16-binding protein-like transcript (MULTI), H60 family proteins and the five retinoic acid-inducible proteins RAE-1α, β, γ, δ, ε. Interaction of CD314 with its ligands regulates cytotoxic response towards the cells bearing the cognate ligands.
Additional information: Clone REA1175 displays negligible binding to Fc receptors.

Alternative names

Klrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d

Detailed product information

Technical specifications

CloneREA1175
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD314 (NKG2D)
Alternative names of antigenKlrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d
Molecular mass of antigen [kDa]27
Distribution of antigenT cells, NK cells, macrophages, dendritic cells, NKT cells
Entrez Gene ID27007
RRIDAB_2784131, AB_2784135, AB_2784134, AB_2784132, AB_2784133

References for CD314 (NKG2D) Antibody, anti-mouse, REAfinity™

Publications

  1. Diefenbach, A. et al. (2000) Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1(2): 119-126
  2. McMahon, C. et al. (2002) The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 17(1): 19-29
  3. Yokoyama, W. M. et al. (2002) NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3(12): 1150-1155
  4. Takada, A. et al. (2008) Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J. Immunol. 180: 1678-1685

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