Clone:
REA419
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
FLT-4, FLT41, LMPH1A, PCL, VEGFR3

Specifications for CD310 (VEGFR-3) Antibody, anti-human, REAfinity™

Overview

Clone REA419 recognizes the human CD310 antigen, a single-pass type I membrane protein also known as vascular endothelial growth factor receptor 3 (VEGFR-3) or Fms-like tyrosine kinase 4 (FLT-4). CD310 is a tyrosine-protein kinase that acts as a cell-surface receptor for the vascular endothelial growth factors VEGF-C and VEGF-D. It plays an essential role in adult lymph-angiogenesis, in the development of the vascular network, and the cardiovascular system during embryonic development. During early embryogenesis all endothelial cells express CD310, while in the adult tissues, CD310 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. CD310 plays a major role in tumor growth and metastatic tumor cell dissemination. The receptor is over-expressed on lymphatic vessels in the vicinity of tumors and on the tumor vasculature and therefore may be an excellent target for an effective cancer intervention.
Additional information: Clone REA419 displays negligible binding to Fc receptors.

Alternative names

FLT-4, FLT41, LMPH1A, PCL, VEGFR3

Detailed product information

Technical specifications

CloneREA419
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD310 (VEGFR-3)
Alternative names of antigenFLT-4, FLT41, LMPH1A, PCL, VEGFR3
Molecular mass of antigen [kDa]150
Distribution of antigenendothelial cells
Entrez Gene ID2324
RRIDAB_2657318, AB_2657319, AB_2657324, AB_2657325, AB_2657326, AB_2657327, AB_2657328, AB_2657329

References for CD310 (VEGFR-3) Antibody, anti-human, REAfinity™

Publications

  1. Achen, M. G. et al. (1998) Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc. Natl. Acad. Sci. U.S.A. 95(2): 548-553
  2. Pajusola, K. et al. (1992) FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res. 52(20): 5738-5743
  3. Tammela, T. et al. (2011) VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat. Cell Biol. 13(10): 1202-1213

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