Clone:
REA440
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
FcRL1, FcRH1, IFGP1, IRTA5

Specifications for CD307a (FcRL1) Antibody, anti-human, REAfinity™

Overview

Clone REA440 recognizes the human CD307a antigen, a single-pass type I membrane protein which is also known as Fc receptor-like protein 1 (FcRL1) or immune receptor translocation-associated protein 5 (IRTA5). CD307a is preferentially expressed on naive and memory B cells. It has two ITAM-like motifs, an acidic glutamic acid residue in its transmembrane region, and three extracellular immunoglobulin-like domains. Ligands for CD307a have not been identified, but the presence of ITAM-like motifs suggests its potential for B cell–activation.
Additional information: Clone REA440 displays negligible binding to Fc receptors.

Alternative names

FcRL1, FcRH1, IFGP1, IRTA5

Detailed product information

Technical specifications

CloneREA440
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD307a (FcRL1)
Alternative names of antigenFcRL1, FcRH1, IFGP1, IRTA5
Molecular mass of antigen [kDa]45
Distribution of antigenB cells
Entrez Gene ID115350
RRIDAB_2657232, AB_2657233, AB_2657234, AB_2657235, AB_2657236, AB_2657237, AB_2657238, AB_2657231

References for CD307a (FcRL1) Antibody, anti-human, REAfinity™

Publications

  1. Leu, C. M. et al. (2005) FcRH1: an activation coreceptor on human B cells. Blood 105(3): 1121-1126
  2. Polson, A. G. et al. (2006) Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. Int. Immunol. 18(9): 1363-1373
  3. Davis, R. S. et al. (2001) Identification of a family of Fc receptor homologs with preferential B cell expression. Proc. Natl. Acad. Sci. U.S.A. 98(17): 9772-9777

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