Clone:
REA447
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
hLAIR1, CD305, LAIR-1

Specifications for CD305 (LAIR-1) Antibody, anti-human, REAfinity™

Overview

Clone REA447 recognizes the human CD305 antigen, a single-pass type I membrane protein which is also known as leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1). CD305 contains a single extracellular immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. It is structurally related to several other inhibitory Ig superfamily members. CD305 is expressed on almost all immune cells, including NK cells, T cells, B cells, monocytes, monocyte-derived dendritic cells, eosinophils, basophils, and mast cells. Besides being expressed on differentiated peripheral blood cells, the receptor is also present on CD34
+
hematopoietic progenitor cells and on the majority of thymocytes. Cross-linking of CD305 on human NK cells delivers a potent inhibitory signal that is capable of inhibiting target cell lysis by resting and activated NK cells. Furthermore, CD305 can inhibit the cytotoxic activity of effector T cells upon CD3 cross-linking or antigen stimulation. In primary B cells, CD305 cross-linking leads to decreased BCR-induced calcium mobilization and down-regulation of Ig and cytokine production.
Additional information: Clone REA447 displays negligible binding to Fc receptors.

Alternative names

hLAIR1, CD305, LAIR-1

Detailed product information

Technical specifications

CloneREA447
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD305 (LAIR-1)
Alternative names of antigenhLAIR1, CD305, LAIR-1
Molecular mass of antigen [kDa]28
Distribution of antigenB cells, dendritic cells, monocytes, NK cells, mast cells, T cells, basophils, eosinophils, thymocytes
Entrez Gene ID3903
RRIDAB_2857836, AB_2657221, AB_2657222, AB_2657225, AB_2657226, AB_2657227, AB_2657228, AB_2657229, AB_2657230, AB_2857839

References for CD305 (LAIR-1) Antibody, anti-human, REAfinity™

Publications

  1. Meyaard, L. et al. (1997) LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 7(2): 283-290
  2. Meyaard, L. (2008) The inhibitory collagen receptor LAIR-1 (CD305). J. Leukoc. Biol. 83(4): 799-803
  3. Perbellini, O. et al. (2014) Clinical significance of LAIR1 (CD305) as assessed by flow cytometry in a prospective series of patients with chronic lymphocytic leukemia. Haematologica 99(5): 881-887

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