Clone:
REA509
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
BIMLEC, CLEC13A, DCL1, KIAA0022

Specifications for CD302 (CLEC13A) Antibody, anti-human, REAfinity™

Overview

Clone REA509 recognizes the human CD302 antigen, a single-pass type I membrane protein, which is also known as C-type lectin domain family 13 member A (CLEC13A) or DCL-1. The C-type lectin superfamily is a large group of proteins which are characterized by the presence of one or more C-type lectin-like domains (CTLDs). The superfamily is divided into 17 groups based on their phylogeny and domain organisation. Despite the presence of a highly conserved domain, C-type lectins are functionally diverse and have been implicated in various processes including cell adhesion, tissue integration and remodelling, platelet activation, complement activation, pathogen recognition, endocytosis, and phagocytosis. CD302 was identified as a genetic fusion partner of human CD205 (DEC-205) in Hodgkin's lymphoma cell lines and is classified as a group XV C-type lectin. The receptor consists of a single extracellular CTLD, a short spacer followed by a transmembrane region, and a cytoplasmic tail containing a putative tyrosine-based internalisation motif. Human CD302 is expressed on monocytes, macrophages, granulocytes, and dendritic cells.
Additional information: Clone REA509 displays negligible binding to Fc receptors.

Alternative names

BIMLEC, CLEC13A, DCL1, KIAA0022

Detailed product information

Technical specifications

CloneREA509
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD302 (CLEC13A)
Alternative names of antigenBIMLEC, CLEC13A, DCL1, KIAA0022
Molecular mass of antigen [kDa]24
Distribution of antigendendritic cells, granulocytes, macrophages, monocytes
Entrez Gene ID9936
RRIDAB_2657184, AB_2657185, AB_2657186, AB_2657187, AB_2657188, AB_2657189, AB_2657190, AB_2657183

References for CD302 (CLEC13A) Antibody, anti-human, REAfinity™

Publications

  1. Kato, M. et al. (2003) Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. J. Biol. Chem. 278(36): 34035-34041
  2. Kerrigan, A. M. et al. (2009) C-type lectins and phagocytosis. Immunobiology 214(7): 562-575

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