Clone:
REA581
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Clec10a, MMGL, M-ASGP-BP-1

Specifications for CD301a (MGL1) Antibody, anti-mouse, REAfinity™

Overview

Clone REA581 recognizes the mouse CD301a antigen, a type II transmembrane glycoprotein also known as macrophage galactose-type C-type lectin-1 (MGL1). CD301 has two genes, CD301a and CD301b, which are highly homologous. In contrast to CD301b, that recognizes N-acetylgalactosamine and galactose, including the O-linked Tn antigen, TF antigen, and core 2, CD301a is highly specific for Lewis X and Lewis A structures. It has been suggested that MGL1 is involved in the clearance of apoptotic cells. CD301a is expressed in alternatively activated macrophages.
Additional information: Clone REA581 displays negligible binding to Fc receptors.

Alternative names

Clec10a, MMGL, M-ASGP-BP-1

Detailed product information

Technical specifications

CloneREA581
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD301a (MGL1)
Alternative names of antigenClec10a, MMGL, M-ASGP-BP-1
Molecular mass of antigen [kDa]35
Distribution of antigenmacrophages
Entrez Gene ID17312
RRIDAB_2657173, AB_2657174, AB_2657177, AB_2657178, AB_2657179, AB_2657180, AB_2657181, AB_2657182

References for CD301a (MGL1) Antibody, anti-mouse, REAfinity™

Publications

  1. Raes, G. et al. (2005) Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J. Leukoc. Biol. 77(3): 321-327
  2. Singh, S. K. et al. (2009) Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties. Mol. Immunol. 46(6): 1240-1249
  3. Yuita, H. et al. (2005) Retardation of removal of radiation-induced apoptotic cells in developing neural tubes in macrophage galactose-type C-type lectin-1-deficient mouse embryos. Glycobiology 15(12): 1368-1375

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