Clone:
REA586
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Clec10a, C-type lectin superfamily member 14, Macrophage lectin 2, MGL

Specifications for CD301 (CLEC10A) Antibody, anti-human, REAfinity™

Overview

Clone REA586 recognizes the human CD301 (CLEC10A) antigen, which is a 40 kDa type II transmembrane glycoprotein expressed by immature DCs and activated macrophages. CD301 is a member of the C-type lectin/C-type lectinl–ike domain (CTL/CTLD) superfamily which plays a role in cell adhesion, cell-cell signaling, glycoprotein turnover, inflammation, and immune response. CD301 binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These moieties are known as Tn-Ag which are expressed in a variety of carcinoma cells.
Additional information: Clone REA586 displays negligible binding to Fc receptors.

Alternative names

Clec10a, C-type lectin superfamily member 14, Macrophage lectin 2, MGL

Detailed product information

Technical specifications

CloneREA586
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD301 (CLEC10A)
Alternative names of antigenClec10a, C-type lectin superfamily member 14, Macrophage lectin 2, MGL
Molecular mass of antigen [kDa]35
Distribution of antigenmacrophages
Entrez Gene ID10462
RRIDAB_2657161, AB_2657162, AB_2657159

References for CD301 (CLEC10A) Antibody, anti-human, REAfinity™

Publications

  1. Suzuki, N. et al. (1996) Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen. J. Immunol. 156(1): 128-135
  2. Napoletano, C. et al. (2012) Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. Eur. J. Immunol. 42(4): 936-945

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