Clone:
OKT3
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
mouse IgG2aκ
Applications:
FA
Alternative names:
CD3e, IMD18, T3E, TCRE

Specifications for CD3 Antibody, anti-human

Overview

The CD3 antibody recognizes the human CD3 antigen which is present on mature human T cells, thymocytes, and NKT cells. The epitope recognized by the antibody is located on the ε-chain of the CD3 complex. Clone OKT3 has been shown to activate T cell function.
Activation and proliferation of T cells can be induced by interaction of the T cell receptor with peptide-MHC complexes expressed on the surface of antigen-presenting cells (APCs). The T cell receives a signal transduced through the CD3 complex. Cytokines or other costimulatory signals are required in addition. Activated T cells can be used for any downstream processes, such as cytokine analysis or immunoprecipitation. Cells can also be transfected with high efficiency.

Applications

The CD3 antibodies – functional grade are suited for functional assays, for example,
in vitro
activation and expansion of T cells in combination with CD2 and CD28 pure – functional grade antibodies, or CD2- and CD28-Biotin – functional grade antibodies, and Anti-Biotin MACSiBead™ Particles, cell culture grade.

Alternative names

CD3e, IMD18, T3E, TCRE

Detailed product information

Technical specifications

CloneOKT3
Clonalitymonoclonal
Isotypemouse IgG2aκ
Hostmouse
Type of antibodyPrimary antibodies, Functional-grade antibodies
Specieshuman
AntigenCD3
Alternative names of antigenCD3e, IMD18, T3E, TCRE
Molecular mass of antigen [kDa]56(sum of molecular weights of subunits)
Distribution of antigenNK cells, T cells, thymocytes
Entrez Gene ID915, 916, 917
RRIDAB_1036144, AB_1036126

References for CD3 Antibody, anti-human

Publications

  1. Lécureuil et al. (2007) Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients. Blood 109: 3649-3657

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