Clone:
REA361
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
LEPR, LEP-R, LEPRD, OB-R, OBR, HuB219 (B219)

Specifications for CD295 (LEPR) Antibody, anti-human, REAfinity™

Overview

Clone REA361 recognizes the human CD295 antigen, a single-pass type I membrane protein which is also known as leptin receptor (LEPR). CD295 is a member of the type I cytokine receptor family which acts through Janus kinases and signal transducers and activators of transcription. It is predominantly expressed in the central nervous system and in multiple tissues, including the choroid plexus, lung, kidney, and primitive hematopoietic cell populations. CD295 is the receptor for leptin, a peptide hormone which is secreted by the adipose tissue at levels roughly proportional to fat content. Leptin communicates the repletion of peripheral energy stores to the brain, suppressing feeding and permitting/promoting energy expenditure via a variety of neuroendocrine and autonomic mechanisms.
Additional information: Clone REA361 displays negligible binding to Fc receptors.

Alternative names

LEPR, LEP-R, LEPRD, OB-R, OBR, HuB219 (B219)

Detailed product information

Technical specifications

CloneREA361
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD295 (LEPR)
Alternative names of antigenLEPR, LEP-R, LEPRD, OB-R, OBR, HuB219 (B219)
Molecular mass of antigen [kDa]130
Distribution of antigenstem cells, hematopoietic stem and progenitor cells, brain, kidney, lung
Entrez Gene ID3953
RRIDAB_2876931, AB_2876932, AB_2657018, AB_2657019, AB_2657024, AB_2657025, AB_2657026, AB_2657027, AB_2657028, AB_2657029

References for CD295 (LEPR) Antibody, anti-human, REAfinity™

Publications

  1. Tartaglia, L. A. et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83(7): 1263-1271
  2. Cioffi, J. A. et al. (1996) Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med 2(5): 585-589
  3. Villanueva, E. C. et al. (2008) Leptin receptor signaling and the regulation of mammalian physiology. Int. J. Obes. (Lond.) 32(7): 8-12

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