Clone:
REA806
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
T44, Tp44

Specifications for CD28 Antibody, anti-mouse, REAfinity™

Overview

Clone REA806 recognizes the mouse CD28 antigen, a costimulatory molecule, expressed on most thymocytes, CD4
+
and CD8
+
T cells, and NK cells. Expression is down-regulated at late stages of terminal effector T cell differentiation. CD28 is a homodimeric type I transmembrane protein of the Ig receptor superfamily, composed of disulfide-linked 45 kDa subunits. Ligation of CD28 with CD80 (B7-1) and CD86 (B7-2) provides a costimulatory signal for T cell activation.
Additional information: Clone REA806 displays negligible binding to Fc receptors.

Alternative names

T44, Tp44

Detailed product information

Technical specifications

CloneREA806
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD28
Alternative names of antigenT44, Tp44
Molecular mass of antigen [kDa]23
Distribution of antigenT cells, B cells, lymphocytes, thymocytes
Entrez Gene ID12487
RRIDAB_2656964, AB_2656965, AB_2656966, AB_2656967, AB_2656963

References for CD28 Antibody, anti-mouse, REAfinity™

Publications

  1. Gross, J. A. et al. (1990) The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression. J. Immunol. 144(8): 3201-3210
  2. Harper, K. et al. (1991) CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J. Immunol. 147(3): 1037-1044

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