Clone:
BT3.1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
BTN3A1, BTF5, BT3.1, BTN3.1, BTN3A2, BT3.2, BTF4, BTN3.2

Specifications for CD277 Antibody, anti-human

Overview

Clone BT3.1 recognizes the human CD277 antigen, a single-pass type I membrane protein, which is also known as butyrophilin subfamily 3 member A1 (BTN3A1). CD277 belongs to the B7 family members and is expressed in various immune cells such as T cells, B cells, monocytes, NK cells, dendritic cells, a subset of stem cells, and endothelial cells. It is also consistently expressed in stromal and some tumor cells. CD277 triggering considerably enhances T cell receptor (TCR) induced cytokine production and cell proliferation. It mediates the response of T cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.

Alternative names

BTN3A1, BTF5, BT3.1, BTN3.1, BTN3A2, BT3.2, BTF4, BTN3.2

Detailed product information

Technical specifications

CloneBT3.1
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD277
Alternative names of antigenBTN3A1, BTF5, BT3.1, BTN3.1, BTN3A2, BT3.2, BTF4, BTN3.2
Molecular mass of antigen [kDa]54
Distribution of antigenB cells, dendritic cells, endothelial cells, monocytes, T cells, stromal cells, cancer stem cells
Entrez Gene ID11119
RRIDAB_2733799, AB_2857721, AB_2857716, AB_2656909, AB_2656910, AB_2733798

References for CD277 Antibody, anti-human

Publications

  1. Messal, N. et al. (2011) Differential role for CD277 as a co-regulator of the immune signal in T and NK cells. Eur. J. Immunol. 41(12): 3443-3454
  2. Tazi-Ahnini, R. et al. (1997) Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex. Immunogenetics 47(1): 55-63

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