Clone:
REA986
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Alternative names:
PDCD1LG2, B7-DC, Btdc, PD-L2

Specifications for CD273 (PD-L2) Antibody, anti-mouse, REAfinity™

Overview

Clone REA986 recognizes CD273, a member of the B7 family of protein ligands. CD273, along with another member of the B7 family (B7-H1) are ligands of T-cell receptor known as programmed death-1 (PD-1). Surface expression of B7-DC is restricted to dendritic cells (DCs) and activated or IFNγ-stimulated DCs and macrophages. CD273/PD-1 interaction is involved in inhibition of T-cell activation, however a co-stimulatory role of CD273, via interaction with receptor other then PD-1 is also reported.
Additional Information: Clone REA986 displays negligible binding to Fc receptors.

Alternative names

PDCD1LG2, B7-DC, Btdc, PD-L2

Detailed product information

Technical specifications

CloneREA986
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD273 (PD-L2)
Alternative names of antigenPDCD1LG2, B7-DC, Btdc, PD-L2
Molecular mass of antigen [kDa]26
Distribution of antigendendritic cells, macrophages
Entrez Gene ID58205

References for CD273 (PD-L2) Antibody, anti-mouse, REAfinity™

Publications

  1. Tseng, S. Y. et al. (2001)
    B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
    J. Exp. Med. 193: 839-846
  2. Wang, S. et al. (2003) Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J. Exp. Med. 197: 1083
  3. Greenwald, R. J. et al. (2005) The B7 family revisited. Annu. Rev. Immunol. 23: 515-548