Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
BTLA, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein

Specifications for CD272 (BTLA) Antibody, anti-mouse, REAfinity™


Clone REA224 recognizes the mouse CD272 antigen, which is also known as B- and T-lymphocyte attenuator (BTLA) or B- and T-lymphocyte-associated protein. CD272, an Ig domain superfamily receptor protein with similarities to cytotoxic T-lymphocyte antigen-4 and programmed death-1, is expressed on various cell types like splenic T and B cells, macrophages, NK cells, dendritic cells as well as lymph node tissues but very weakly in somatic tissues. A polymorphic tissue distribution between several mouse strains is seen. Crosslinking CD272 with antigen receptors results in downregulation of T cell activation and attenuates production of interleukin 2. CD272 deficient mice have increased specific antibody responses and enhanced incidence and severity of autoimmune disorders.
Additional information: Clone REA224 displays negligible binding to Fc receptors.

Alternative names

BTLA, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
AntigenCD272 (BTLA)
Alternative names of antigenBTLA, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein
Molecular mass of antigen [kDa]31
Distribution of antigenB cells, NK cells, T cells
Entrez Gene ID208154
RRIDAB_2656857, AB_2656858, AB_2656859, AB_2656860, AB_2656861, AB_2656856

References for CD272 (BTLA) Antibody, anti-mouse, REAfinity™


  1. Watanabe, N. et al. (2003) BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 4(7): 670-679
  2. Kobayashi, Y. et al. (2013) B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc. Natl. Acad. Sci. U.S.A. 110: 5121-5126
  3. Murphy, T. L. et al. (2010) Slow down and survive: Enigmatic immunoregulation by BTLA and HVEM. Annu. Rev. Immunol. 28: 389-411

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