Clone:
REA648
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
NGFR (p75), p75NGFR, p75NTR, TNFRSF16, CD271, Gp80-LNGFR

Specifications for CD271 (LNGFR) Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA648 recognizes the CD271 antigen, a type I transmembrane glycophosphoprotein, also known as low-affinity nerve growth factor receptor (LNGFR) or p75 neurotrophin receptor (p75 NTR). CD271 belongs to the low-affinity neurotrophin receptors and the tumor necrosis factor receptor superfamily. Initially the human CD271 was described to be expressed on cells of the central and peripheral nervous system, and was suggested to be involved in the development, survival, and differentiation of cells. Binding of neutrophins to the CD271 receptor initiates the stimulation of neuronal cells to survive and differentiate. CD271 is expressed on mesenchymal stem/stromal cells (MSCs), follicular dendritic cells, mesenchymal cells involved in mesenchymal-epithelial interactions, autonomic and sensory neurons, oligodendrocytes, astrocytes, schwann cells, and neural crest stem cells.
Additional information: Clone RE648 displays negligible binding to Fc receptors.

Alternative names

NGFR (p75), p75NGFR, p75NTR, TNFRSF16, CD271, Gp80-LNGFR

Detailed product information

Technical specifications

CloneREA648
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, non-human primate
Cross-reactivityguinea pig, rat,
rhesus monkey (
Macaca mulatta
)
AntigenCD271 (LNGFR)
Alternative names of antigenNGFR (p75), p75NGFR, p75NTR, TNFRSF16, CD271, Gp80-LNGFR
Molecular mass of antigen [kDa]42
Distribution of antigenstromal cells, stem cells, dendritic cells, oligodendrocytes, Schwann cells, mesenchymal stem cells, neural stem cells
Entrez Gene ID18053
RRIDAB_2751559, AB_2727642, AB_2727572, AB_2811422, AB_2811410, AB_2819755, AB_2819752, AB_2857748, AB_2656844, AB_2656852, AB_2656853, AB_2751570

Resources for CD271 (LNGFR) Antibody, anti-human/mouse, REAfinity™

References for CD271 (LNGFR) Antibody, anti-human/mouse, REAfinity™

Publications

  1. Caneva, L. et al. (1995) Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies. Blood Cells Mol. Dis. 21: 73-85
  2. Quirici, N. et al. (2002) Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies. Exp. Hematol. 30: 783-791
  3. Casaccia-Bonnefil, P. et al. (1996) Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 383: 716-719
  4. Huber, L. J. and Chao, M. V. (1995) Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanisms. Dev. Biol. 167: 227-238
  5. Chalazonitis, A. et al. (1998)
    Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRalpha-1
    in vitro
    and
    in vivo
    .
    Dev. Biol. 204(2): 385-406
  6. Jones, E. A. et al. (2002) Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum. 46: 3349-3360
  7. Kashiba, H. et al. (1995) Coexpression of trk family members and low-affinity neurotrophin receptors in rat dorsal root ganglion neurons. Brain Res. Mol. Brain Res. 30(1): 158-164
  8. Rudge, J. S. et al. (1994) Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes. Eur. J. Neurosci. 6: 693-705
  9. Thomson, T. M. et al. (1988) Expression of human nerve growth factor receptor on cells derived from all three germ layers. Exp. Cell Res. 174: 533-539
  10. Pezzati, P. et al. (1992) Expression of nerve growth factor receptor immunoreactivity on follicular dendritic cells from human mucosa associated lymphoid tissues. Immunology 76: 485-490
  11. Rozemuller, H. et al. (2010) Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies. Stem Cells Dev. 19: 1911-1921
  12. Vroemen, M. and Weidner, N. (2003) Purification of Schwann cells by selection of p75 low affinity nerve growth factor receptor expressing cells from adult peripheral nerve. J. Neurosci. Methods 124: 135-143

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