Clone:
REA275
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
TNFRSF14, ATAR, HVEA, HVEM, Tnfrs14

Specifications for CD270 (HVEM) Antibody, anti-mouse, REAfinity™

Overview

Clone REA275 recognizes the CD270 antigen, a type I transmembrane protein of the TNF-receptor superfamily which is also known as Herpes virus entry mediator (HVEM) or tumor necrosis factor receptor like 2 (TR2). CD270 is expressed in multiple tissues and cell lines and shows a constitutive and relatively high expression in peripheral blood T cells, B cells, monocytes, neutrophils and dendritic cells. Both human and mouse forms of CD270 can mediate entry of herpes simplex virus-1 and -2 (HSV-1 and HSV-2). CD270 transmits both activating and inhibitory signals; e.g interaction with receptors such as BTLA or CD160 attenuates TCR-mediated signaling, whereas interaction with receptor LIGHT allows co-stimulation of T and B cells.
Additional information: Clone REA275 displays negligible binding to Fc receptors.

Alternative names

TNFRSF14, ATAR, HVEA, HVEM, Tnfrs14

Detailed product information

Technical specifications

CloneREA275
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD270 (HVEM)
Alternative names of antigenTNFRSF14, ATAR, HVEA, HVEM, Tnfrs14
Molecular mass of antigen [kDa]26
Distribution of antigenB cells, dendritic cells, monocytes, T cells
Entrez Gene ID230979
RRIDAB_2656839, AB_2656840, AB_2656841, AB_2656842, AB_2656843, AB_2656838

References for CD270 (HVEM) Antibody, anti-mouse, REAfinity™

Publications

  1. Hsu, H. et al. (1997) ATAR, a novel tumor necrosis factor receptor family member, signal through TRAF2 and TRAF5. J. Biol. Chem. 272: 13471-13474
  2. Kwon, B. S. et al. (1997) A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. J. Biol. Chem. 272: 14272-14276
  3. Kim, W. K. et al. (2012) Absence of herpes virus entry mediator (HVEM) increases bone mass by attenuating receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis. Endocrinology 153(10): 4808-4817

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