Clone:
7H22-E16
Type of antibody:
Primary antibodies
Isotype:
rat IgG1κ
Applications:
FC
Alternative names:
TNFRSF13c, BR3, BAFFR, Bcmd, Bcmd-1, Lvis22

Specifications for CD268 Antibody, anti-mouse

Overview

Clone 7H22-E16 reacts with CD268, also known as B cell activation factor receptor (BAFF-R), a type III transmembrane TNF receptor family member. CD268 is expressed at high levels on resting B cells, at lower levels on activated B cells, and on a small subset of activated/memory T cells. BAFF, also known as BLys, mediates costimulatory responses in peripheral B and T cells. BAFF is a key regulator for B cell differentiation as well as survival and activation of peripheral B cell populations. Accordingly, CD268 appears to be particularly involved in the regulation of normal B cell survival and maturation, but also in the pathophysiology of aggressive B cell malignancies and autoimmune diseases.

Alternative names

TNFRSF13c, BR3, BAFFR, Bcmd, Bcmd-1, Lvis22

Detailed product information

Technical specifications

Clone7H22-E16
Clonalitymonoclonal
Isotyperat IgG1κ
Isotype controlIsotype Control Antibody, rat IgG1
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD268
Alternative names of antigenTNFRSF13c, BR3, BAFFR, Bcmd, Bcmd-1, Lvis22
Molecular mass of antigen [kDa]19
Distribution of antigenB cells, T cells, leukocytes, lymphocytes, spleen
Entrez Gene ID72049
RRIDAB_2660670, AB_2660671, AB_2660672, AB_2660673, AB_2660674, AB_2660669

References for CD268 Antibody, anti-mouse

Publications

  1. Ng, L. G. et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol. 173(2): 807-817
  2. Thompson, J. S. et al. (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293(5537): 2108-2111
  3. Ng, L. G. et al. (2006) BAFF costimulation of Toll-like receptor-activated B-1 cells. Eur. J. Immunol. 36(7): 1837-1846
  4. Yan, M. et al. (2001) Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr. Biol. 11(19): 1547-1552

Related products for
CD268 Antibody, anti-mouse

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?