Clone:
REA1026
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC

Specifications for CD254 (RANKL) Antibody, anti-mouse, REAfinity™

Overview

Clone REA1026 recognizes the mouse CD254 antigen, also known as receptor activator of nuclear factor kappa-B ligand (RANKL) or TNF-related activation-induced cytokine (TRANCE). CD254 is an essential osteoclastic differentiation and activation factor which has multiple roles in the immune system. It is reported that RANK and CD254 (RANKL) may be important regulators of interactions between T cells and dendritic cells and is involved in the regulation of the T cell–dependent immune response. CD254 is expressed on osteoplastsand dendritic cells.
Additional information: Clone REA1026 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA1026
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD254 (RANKL)
Distribution of antigendendritic cells, osteoblasts, T cells
Entrez Gene ID21943
RRIDAB_2727874, AB_2727911, AB_2727875, AB_2727912, AB_2727876, AB_2727913, AB_2727877, AB_2727914, AB_2727878, AB_2727910

References for CD254 (RANKL) Antibody, anti-mouse, REAfinity™

Publications

  1. Anderson, D. M. et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390(6656): 175-179
  2. Bekker, P. J. et al. (2004) A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J. Bone Miner. Res. 19(7): 1059-1066
  3. Luan, X. et al. (2012) Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. J. Immunol. 189(1): 245-252

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