Clone:
DN254
Type of antibody:
Primary antibodies
Isotype:
human IgG2
Applications:
FC, MICS, IF, IHC
Alternative names:
TNFSF11, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf

Specifications for CD254 (RANKL) Antibody, anti-human

Overview

Clone DN254 recognizes the human CD254 antigen, also known as receptor activator of nuclear factor kappa-B ligand (RANKL) or TNF-related activation-induced cytokine (TRANCE). CD254 is an essential osteoclastic differentiation and activation factor which plays multiple roles in the immune system. It is reported, that RANK and CD254 (RANKL) may be important regulators of interactions between T cells and dendritic cells and is involved in the regulation of the T cell–dependent immune response. CD254 is expressed in the peripheral lymph nodes, in spleen, peripheral blood leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach, and thyroid.

Alternative names

TNFSF11, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf

Detailed product information

Technical specifications

CloneDN254
Clonalitymonoclonal
Isotypehuman IgG2
Hosthuman
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD254 (RANKL)
Alternative names of antigenTNFSF11, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Molecular mass of antigen [kDa]36
Distribution of antigenleukocytes, bone marrow, heart, lymph node, placenta, skeletal muscle, spleen
Entrez Gene ID8600
RRIDAB_2656690, AB_2656691, AB_2656692, AB_2656693

References for CD254 (RANKL) Antibody, anti-human

Publications

  1. Luan, X. et al. (2012) Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. J. Immunol. 189(1): 245-252
  2. Anderson, D. M. et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390(6656): 175-179
  3. Bekker, P. J. et al. (2004) A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J. Bone Miner. Res. 19(7): 1059-1066

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