Clone:
REA1113
Type of antibody:
Recombinant antibodies, Primary antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
TNFSF10, APO2L, Apo-2L, TL2, TRAIL

Specifications for CD253 Antibody, anti-human, REAfinity™

Overview

Clone REA1113 recognizes the human CD253 cytokine, a type II transmembrane protein also known as TNF-related apoptosis inducing ligand (TRAIL) or tumor necrosis factor ligand superfamily member 10 (TNFSF10), which induces the process of cell death. CD253 is predominantly found in spleen, lung, and prostate. It binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). CD253 can be expressed on transformed and virus infected cells. It can also be expressed on activated lymphocytes.
Additional information: Clone REA1113 displays negligible binding to Fc receptors.

Alternative names

TNFSF10, APO2L, Apo-2L, TL2, TRAIL

Detailed product information

Technical specifications

CloneREA1113
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyRecombinant antibodies, Primary antibodies
Specieshuman
AntigenCD253
Alternative names of antigenTNFSF10, APO2L, Apo-2L, TL2, TRAIL
Molecular mass of antigen [kDa]33
Distribution of antigenB cells, dendritic cells, T cells, monocytes, NK cells, lymphocytes
Entrez Gene ID8743
RRIDAB_2751671, AB_2751692, AB_2751672, AB_2751693, AB_2751673, AB_2751691

References for CD253 Antibody, anti-human, REAfinity™

Publications

  1. Wiley, S. R. et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3(6): 673-682
  2. Pitti, R. M. et al. (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271(22): 12687-12690
  3. Almasan, A. et al. (2003) Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. Cytokine Growth Factor Rev. 14(3-4): 337-348

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CD253 Antibody, anti-human, REAfinity™

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