Clone:
ATM-2
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
mouse IgG1κ
Applications:
FA, FC
Alternative names:
TNFSF4, OX40L

Specifications for CD252 (OX40L) Antibody, anti-rat

Overview

Clone ATM-2 recognizes the rat CD252 antigen, a member of the TNF ligand superfamily, also known as OX40 ligand (OX40L) or tumor necrosis factor ligand superfamily member 4 (TNSFSF4). CD252 is constitutively expressed by splenic dendritic cells and can be upregulated on splenic B cells via stimulation with LPS. Expression of the cognate receptor CD134 (OX40) is found predominantly on activated T cells. CD252/CD134 interaction promotes the proliferation and survival of effector T cells, modulates cytokine production, suppresses the activity of natural regulatory T cells, and inhibits the generation of inducible regulatory T cells.

Alternative names

TNFSF4, OX40L

Detailed product information

Technical specifications

CloneATM-2
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesrat
AntigenCD252 (OX40L)
Alternative names of antigenTNFSF4, OX40L
Molecular mass of antigen [kDa]22
Distribution of antigenB cells, dendritic cells, T cells, thymocytes
Entrez Gene ID89814
RRIDAB_2656676, AB_2656677, AB_2656678, AB_2656679, AB_2727181, AB_2656669

References for CD252 (OX40L) Antibody, anti-rat

Publications

  1. Satake, Y. et al. (2000) Characterization of rat OX40 ligand by monoclonal antibody. Biochem. Biophys. Res. Commun. 270(3): 1041-1048
  2. Paterson, D. J. et al. (1987) Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol. Immunol. 24(12): 1281-1290
  3. Ishii, N. et al. (2010) OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. Adv. Immunol. 105: 63-98

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CD252 (OX40L) Antibody, anti-rat

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