Clone:
REAL1302
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Tumor endothelial marker 1, CD164L1, CD164 sialomucin-like 1, TEM1

Specifications for CD248 (Endosialin) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1302 is an antibody fragment derived from the full CD248 (Endosialin) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1302 recognizes the human CD248 (Endosialin) antigen, also known as Tumor endothelial marker 1 (TEM1) or CD164 sialomucin-like 1 (CD164L1). CD248 is a single-pass type I transmembrane glycoptrotein belonging to the Group XIV, a novel family of C-type lectin transmembrane receptors. CD248 is expressed on tumor endothelial cells, in metastatic lesions of the liver pericytes and on stromal fibroblasts. CD248 is suggested to be involved in tumor angiogenesis,development and growth and in lymphoid tissue organization.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Tumor endothelial marker 1, CD164L1, CD164 sialomucin-like 1, TEM1

Detailed product information

Technical specifications

CloneREAL1302
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD248 (Endosialin)
Alternative names of antigenTumor endothelial marker 1, CD164L1, CD164 sialomucin-like 1, TEM1
Distribution of antigentumor cells, fibroblasts

Resources for CD248 (Endosialin) Antibody, anti-human, REAdye_lease™

Certificates

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References for CD248 (Endosialin) Antibody, anti-human, REAdye_lease™

Publications

  1. Rettig, W. J. (1992) Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. Proc. Natl. Acad. Sci. U.S.A. 89(22): 10832-10836
  2. MacFadyen, J. R. et al. (2005) Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. FEBS Lett. 579(12): 2569-2575
  3. Simonavicius, N. et al. (2008) Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma. Mod Pathol 21(3): 308-315
  4. Viski, C. et al. (2016) Endosialin-Expressing Pericytes Promote Metastatic Dissemination. Cancer Res. 76(18): 5313-5325
  5. Khan, K. A. et al. (2019) C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation. FEBS J. 286(17): 3299-3332

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