Clone:
REA376
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
ACKR1, CCBP1, WBCQ1, DARC, Dfy, FY, GPD, GpFy

Specifications for CD234 (DARC) Antibody, anti-human, REAfinity™

Overview

Clone REA376 recognizes the human CD234 antigen, a multi-pass membrane protein also known as duffy antigen receptor for chemokines (DARC) or Fy glycoprotein (FY). CD234 is responsible for the duffy blood group system and belongs to a family of silent seven-transmembrane spanning receptors, which do not couple to G-proteins and therefore do not transmit intracellular signals like other G-protein–coupled chemokine-receptors leading to integrin activation or cell motility. It binds to a broad range of inflammatory chemokines of both the CC and the CXC chemokine families, but does not interact with homeostatic chemokines. CD234 is expressed on erythrocytes, cerebellar neurons on postcapillary venule, and capillary endothelial cells in a number of peripheral organs including lymph nodes, the lung, and the kidney. In these organs, endothelial CD234 is specifically expressed in the vascular segment involved in leucocyte extravasation. CD234 was shown to mediate chemokine transcytosis from the basolateral to the luminal side of the endothelium, where the chemokines remain immobilized on the tips of endothelial apical microvilli and enhance leucocyte trafficking
in vivo
.
Additional information: Clone REA376 displays negligible binding to Fc receptors.

Alternative names

ACKR1, CCBP1, WBCQ1, DARC, Dfy, FY, GPD, GpFy

Detailed product information

Technical specifications

CloneREA376
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD234 (DARC)
Alternative names of antigenACKR1, CCBP1, WBCQ1, DARC, Dfy, FY, GPD, GpFy
Molecular mass of antigen [kDa]36
Distribution of antigenred blood cells, neurons, lung, lymph node
Entrez Gene ID2532
RRIDAB_2752047, AB_2857811, AB_2857801, AB_2656491, AB_2656492, AB_2752060

References for CD234 (DARC) Antibody, anti-human, REAfinity™

Publications

  1. Chaudhuri, A. et al. (1993)
    Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the
    Plasmodium vivax
    malaria parasite.
    Proc. Natl. Acad. Sci. U.S.A. 90(22): 10793-10797
  2. Graham, G. J. et al. (2012) The biochemistry and biology of the atypical chemokine receptors. Immunol. Lett. 145(1-2): 30-38
  3. Minten, C. et al. (2014) DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation. Brain 137(5): 1454-1469

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