Clone:
REA203
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
PRNP, ASCR, CJD, GSS, KURU, PRIP, PrP, p27-30

Specifications for CD230 (PrP) Antibody, anti-human, REAfinity™

Overview

Clone REA203 recognizes CD230, commonly known as the prion protein (PrP). The normal cellular PrP (PrP
c
) is a ubiquitously expressed glycosylphosphatidyl-inositol (GPI) anchored protein. Though the main function of PrP
c
remains unknown, it has been suggested that PrP
c
may play a role in copper regulation, antioxidant activity, intracellular signaling. PrP
sc
is the conformational isoform of PrP
c
with similar primary sequence but different tertiary structure and is associated with neurodegenerative diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy, and scrapie in sheeps. PrP
sc
is suggested to derive from PrP
c
in a posttranslational process which involves PrP
c
-PrP
sc
molecular interactions.
Additional information: Clone REA203 displays negligible binding to Fc receptors.

Alternative names

PRNP, ASCR, CJD, GSS, KURU, PRIP, PrP, p27-30

Detailed product information

Technical specifications

CloneREA203
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD230 (PrP)
Alternative names of antigenPRNP, ASCR, CJD, GSS, KURU, PRIP, PrP, p27-30
Distribution of antigenother, brain
RRIDAB_2656470, AB_2656471, AB_2656472, AB_2656473, AB_2656474, AB_2656475

References for CD230 (PrP) Antibody, anti-human, REAfinity™

Publications

  1. Maas, E. et al. (2007) Scrapie infection of Prion protein-deficient cell line upon ectopic expression of mutant Prion proteins. J. Biol. Chem. 282: 18702-18710
  2. Basu, S. et al. (2007) Modulation of proteinase K-resistant Prion protein in cells and infectious brain homogenate by redox iron: Implications for prion replication and disease pathogenesis. Mol. Cell. Biol. 18: 3302-3312

Related products for
CD230 (PrP) Antibody, anti-human, REAfinity™

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?