Clone:
REA947
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL-18Ra, IL-18Rα, IL-18R1, IL-18R-1, IL-1Rrp

Specifications for CD218a (IL-18Rα) Antibody, anti-mouse, REAfinity™

Overview

Clone REA947 recognizes the mouse CD218a antigen, also known as interleukin-18 receptor alpha (IL-18Rα). CD218a, a member of the immunoglobulin superfamily, is a subunit of the heterodimeric receptor complex of alpha- and beta-chains for the pleiotropic proinflammatory IL-18 cytokine. IL-18 belongs to the IL-1 superfamily and is expressed by monocytes, macrophages, epithelial cells, and keratinocytes. CD218a (IL-18Rα) is found on Tʜ1 cells, subsets of NK cells, and granulocytes. IL-18 plays a role in induction of inflammatory mediators, regulation of the cytotoxic activity of NK and T cells, and differentiation and activation of Tʜ1 and Tʜ2 cells.
Additional information: Clone REA947 displays negligible binding to Fc receptors.

Alternative names

IL-18Ra, IL-18Rα, IL-18R1, IL-18R-1, IL-1Rrp

Detailed product information

Technical specifications

CloneREA947
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD218a (IL-18Rα)
Alternative names of antigenIL-18Ra, IL-18Rα, IL-18R1, IL-18R-1, IL-1Rrp
Molecular mass of antigen [kDa]60
Distribution of antigengranulocytes, NK cells, T cells, neutrophils, Th1 cells
Entrez Gene ID16182
RRIDAB_2727158, AB_2727145, AB_2727159, AB_2727146, AB_2727160, AB_2727147, AB_2727156, AB_2727144, AB_2727157

References for CD218a (IL-18Rα) Antibody, anti-mouse, REAfinity™

Publications

  1. Wu, C. et al. (2003) IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. J. Immunol. 170(11): 5571-5577
  2. Sergi, B. et al. (2004) Interleukin 18 receptor. J. Biol. Regul. Homeost. Agents 18(1): 55-61
  3. Huang, H. Y. et al. (2010) Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients. Fertil. Steril. 94(1): 33-39

Related products for
CD218a (IL-18Rα) Antibody, anti-mouse, REAfinity™

2 products available