Clone:
REA242
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL12RB1, IL-12R-BETA1, IL12RB, IMD30, IL-12 receptor β1 subunit

Specifications for CD212 Antibody, anti-human, REAfinity™

Overview

Clone REA242 recognizes CD212, which is also known as interleukin 12 (IL-12) receptor β1 subunit. CD212 is a single-pass type I membrane protein and belongs to the type 2 subfamily of cytokines receptors. It forms a heterodimeric complex with IL-12β2 to form IL-12 receptor and with IL-23R to form IL-23 receptor. IL-12 and IL-23 are heterodimeric cytokines produced mainly by antigen-presenting cells (APCs), such as macrophages, dendritic cells, B cells, and activated T and NK cells.
Additional information: Clone REA242 displays negligible binding to Fc receptors.

Alternative names

IL12RB1, IL-12R-BETA1, IL12RB, IMD30, IL-12 receptor β1 subunit

Detailed product information

Technical specifications

CloneREA242
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
cynomolgus monkey (
Macaca fascicularis
)
,
rhesus monkey (
Macaca mulatta
)
AntigenCD212
Alternative names of antigenIL12RB1, IL-12R-BETA1, IL12RB, IMD30, IL-12 receptor β1 subunit
Molecular mass of antigen [kDa]70
Distribution of antigenB cells, macrophages, NK cells, T cells
Entrez Gene ID3594
RRIDAB_2656317, AB_2656318, AB_2656319, AB_2656320, AB_2656321, AB_2656322

References for CD212 Antibody, anti-human, REAfinity™

Publications

  1. Chang, J. T. et al. (2000) Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity. J. Immunol. 164: 100-106
  2. Nagayama, H. et al. (2000) IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells. J. Immunol. 165: 59-66
  3. Presky, D. H. et al. (1998) Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. J. Immunol. 160: 2174-2179

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