Clone:
REA800
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CR2, C3dR, C3b/C4b-R, CR1, EBV-R, Immune adherence receptor

Specifications for CD21/CD35 Antibody, anti-mouse, REAfinity™

Overview

Clone REA800 recognizes an epitope shared by mouse CD21 and CD35, also known as CR2 and CR1. CD21 and CD35 are alternatively spliced transcripts from the Cr2 gene, which produce cell-surface proteins of 145 and 190 kDa, respectively. CD21 and CD35 are expressed on the majority of peripheral B lymphocytes, on the majority of resident peritoneal macrophages, on mast cells, activated granulocytes, and follicular dendritic cells. CD21 forms part of a signal transduction complex with CD19 and CD81, which are associated with the antigen receptor on B lymphocytes.
Additional information: Clone REA800 displays negligible binding to Fc receptors.

Alternative names

CR2, C3dR, C3b/C4b-R, CR1, EBV-R, Immune adherence receptor

Detailed product information

Technical specifications

CloneREA800
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD21/CD35
Alternative names of antigenCR2, C3dR, C3b/C4b-R, CR1, EBV-R, Immune adherence receptor
Molecular mass of antigen [kDa]112
Distribution of antigenB cells, dendritic cells, macrophages, monocytes, granulocytes, NK cells, T cells, lymphocytes, eosinophils, neutrophils
Entrez Gene ID12902
RRIDAB_2656311, AB_2656312, AB_2656296, AB_2656297, AB_2656298, AB_2656299, AB_2656300, AB_2656301, AB_2656302, AB_2656303, AB_2656304, AB_2656305, AB_2656306, AB_2656307, AB_2656308, AB_2656309, AB_2656310, AB_2656295

References for CD21/CD35 Antibody, anti-mouse, REAfinity™

Publications

  1. Kozono, Y. et al. (1998) Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells. J. Immunol. 160(4): 1565-1572
  2. Brockman, M. A. et al. (2006) Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells. J. Virol. 80(14): 7111-7117
  3. Roozendaal, R. et al. (2007) Complement receptors CD21 and CD35 in humoral immunity. Immunol. Rev. 219: 157-166

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