Clone:
REA125
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
DC-SIGNR1, OtB7, SIGNR1, mSIGNR1

Specifications for CD209b (SIGN-R1) Antibody, anti-mouse, REAfinity™

Overview

Clone REA125 recognizes the mouse CD209b antigen, a single-pass type II membrane protein also known as DC-SIGN-related protein 1 (SIGN-R1). CD209b was identified by examination of the mouse genome in search of the complete set of proteins related to the human glycan binding receptor CD209 (DC-SIGN). Unlike the human CD209, mouse CD209b is not expressed on dendritic cells (DCs) but is on splenic marginal zone, lymph node, and peritoneal macrophages. Its high affinity for murine ICAM-2, and its localization at sites that are in close contact with blood, suggest a role for CD209b in lymphocyte migration from the blood into tissues. Moreover, marginal zone macrophages in the spleen efficiently capture blood-borne antigens
in vivo
through CD209b. CD209b has also been shown to interact with the TLR signaling system, with CD209b associating with the TLR4-MD2 complex to enhance signal transduction in response to LPS in Gram-negative bacteria
in vitro
.
Additional information: Clone REA125 displays negligible binding to Fc receptors.

Alternative names

DC-SIGNR1, OtB7, SIGNR1, mSIGNR1

Detailed product information

Technical specifications

CloneREA125
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD209b (SIGN-R1)
Alternative names of antigenDC-SIGNR1, OtB7, SIGNR1, mSIGNR1
Molecular mass of antigen [kDa]37
Distribution of antigenmacrophages, spleen
Entrez Gene ID69165
RRIDAB_2727966, AB_2801751, AB_2656266, AB_2656267, AB_2656270, AB_2656271, AB_2751424

References for CD209b (SIGN-R1) Antibody, anti-mouse, REAfinity™

Publications

  1. Saunders, S. P. et al. (2001) C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide. J. Immunol. 184(5): 2627-2637
  2. Geijtenbeek, T. B. et al. (2002)
    Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens
    in vivo
    .
    Blood 100(8): 2908-2916
  3. Park, C. G. et al. (2001) Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int. Immunol. 13(10): 1283 -1290

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