Clone:
REA295
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
LAMP3, DC LAMP, Protein TSC403

Specifications for CD208 (DC-LAMP) Antibody, anti-human, REAfinity™

Overview

Clone REA295 recognizes the CD208 antigen, a single-pass type I intracellular protein also known as lysosome-associated membrane glycoprotein 3 (LAMP-3) or DC-lysosome–associated membrane glycoprotein (DC-LAMP). CD208 was first cloned as a gene specifically expressed in lung tissues and found to be overexpressed in primary cancers of the esophagus, colon, fallopian tube, ovary, breast, and liver, although its expression was barely detectable in the corresponding normal tissues. It is almost exclusively expressed by mature dendritic cells (DCs). Expression can be induced in CD34
+
derived dendritic cells by stimulation with GM-CSF and TNF-α or in monocytes by the stimulation with GM-CSF and IL-4. CD208 is found in the MHC class II compartment immediately before the translocation of MHC class II molecules to the cell surface, after which it concentrates into perinuclear lysosomes. This suggests that CD208 might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of DC.
Additional information: Clone REA295 displays negligible binding to Fc receptors.

Alternative names

LAMP3, DC LAMP, Protein TSC403

Detailed product information

Technical specifications

CloneREA295
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD208 (DC-LAMP)
Alternative names of antigenLAMP3, DC LAMP, Protein TSC403
Molecular mass of antigen [kDa]42
Distribution of antigendendritic cells
Entrez Gene ID27074
RRIDAB_2811380, AB_2656242, AB_2656243, AB_2811382

References for CD208 (DC-LAMP) Antibody, anti-human, REAfinity™

Publications

  1. de Saint-Vis, B. et al. (1998) A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity 9(3): 325-336
  2. Bell, D. et al. (1999) In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. J. Exp. Med. 190(10): 1417-1426
  3. Kanao, H. et al. (2005) Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in uterine cervical cancer. Cancer Res. 65(19): 8640-8645

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