Clone:
REA1130
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
LFA-2, SRBC-R, T11, SRBC

Specifications for CD2 Antibody, anti-human, REAfinity™

Overview

Clone REA1130 recognizes the human CD2 antigen, a 50 kDa single-chain transmembrane glycoprotein also known as LFA-2 or receptor for sheep erythrocytes. CD2 functions as a co-stimulatory molecule on T and NK cells and is a receptor for other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58). It belongs to the Ig superfamily and is involved in cell signaling and lymphocyte adhesion. The CD2 antibody reacts with 80–90 % of peripheral blood lymphocytes and more than 95% of thymocytes and recognizes all T cells and a subset of NK cells.
Additional information: Clone REA1130 displays negligible binding to Fc receptors.

Alternative names

LFA-2, SRBC-R, T11, SRBC

Detailed product information

Technical specifications

CloneREA1130
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD2
Alternative names of antigenLFA-2, SRBC-R, T11, SRBC
Molecular mass of antigen [kDa]37
Distribution of antigenB cells, lymphocytes, macrophages, mast cells, NK cells, thymocytes
Entrez Gene ID914
RRIDAB_2876994, AB_2876928, AB_2876968

References for CD2 Antibody, anti-human, REAfinity™

Publications

  1. Sanchez-Madrid, F. et al. (1982) Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc. Natl. Acad. Sci. U.S.A. 79: 7489-7493
  2. Ozwara, H. et al. (1997)
    Flow cytometric analysis on reactivity of human T lymphocyte-specific and cytokine-receptor-specific antibodies with peripheral blood mononuclear cells of chimpanzee (
    Pan troglodytes
    ), rhesus macaque (
    Macacca mulatta
    ) and squirrel monkey (
    Saimiri sciureus
    ).
    J. Med. Primatol. 26(3): 164-171

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