Clone:
REA736
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
HTA1, CD1, FCB6, R4, T6, Leu-6

Specifications for CD1a Antibody, anti-human, REAfinity™

Overview

Clone REA736 recognizes the human CD1a antigen, a 40 kDa type I membrane glycoprotein, also known as T6 or Leu-6, which is a member of the immunglobulin superfamily. It shares functional and structural similarities with MHC I class molecules and is associated with β2-microglobulin. CD1a plays a role in antigen presentation by binding lipid and glycolipid antigens and presenting them to T cell receptors on natural killer T cells. CD1a is expressed on Langerhans cells, dendritic cells, and cortical thymocytes.
Additional information: Clone REA736 displays negligible binding to Fc receptors

Alternative names

HTA1, CD1, FCB6, R4, T6, Leu-6

Detailed product information

Technical specifications

CloneREA736
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD1a
Alternative names of antigenHTA1, CD1, FCB6, R4, T6, Leu-6
Molecular mass of antigen [kDa]35
Distribution of antigenB cells, dendritic cells, Langerhans cells, macrophages, monocytes, lymphocytes, thymocytes
Entrez Gene ID909
RRIDAB_2656004, AB_2656005, AB_2656006, AB_2656007, AB_2656008, AB_2656009, AB_2656010, AB_2656011, AB_2656012, AB_2656013, AB_2656014, AB_2656015, AB_2656016, AB_2656017, AB_2656018, AB_2656003

References for CD1a Antibody, anti-human, REAfinity™

Publications

  1. Hanau, D. et al. (1990) Possible mechanism of action of CD1a antigens. J. Invest. Dermatol. 95(5): 503-505
  2. Calabi, F. et al. (1991) The CD1 system. Tissue Antigens 37(1): 1-9
  3. Blumberg, R. S. et al. (1995) Structure and function of the CD1 family of MHC-like cell surface proteins. Immunol. Rev. 147: 5-29

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