Clone:
REA122
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CCR3, CC-CKR3, CKR3, Cmkbr1l2, CMKBR3

Specifications for CD193 (CCR3) Antibody, anti-mouse, REAfinity™

Overview

Clone REA122 recognizes CD193, also known as CCR3 . CD193 is a seven transmembrane, β chemokine receptor belonging to the family of G protein-coupled receptors. Though CD193 is known primarily for its expression on eosinophils, its abundant expression is also found on mast cells, basophils, platelets and mononuclear phagocytes. CD193 binds to chemokines such as eotaxin-1, -2, -3, monocyte chemotactic proteins-2, -3, -4, RANTES and MIP-1α. An increased expression of these chemokines stimulate cells bearing CCR3 and promote their migration and recruitment at the site of inflammation, such as airway and conjuctiva. Thus, an important role of CD193 has been implicated in various allergic diseases such as bronchial asthma and allergic conjuctivitis.
Additional Information: Clone REA122 displays negligible binding to Fc receptors.

Alternative names

CCR3, CC-CKR3, CKR3, Cmkbr1l2, CMKBR3

Detailed product information

Technical specifications

CloneREA122
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD193 (CCR3)
Alternative names of antigenCCR3, CC-CKR3, CKR3, Cmkbr1l2, CMKBR3
Molecular mass of antigen [kDa]42
Distribution of antigenmast cells, platelets, basophils, eosinophils
Entrez Gene ID12771
RRIDAB_2655876, AB_2655877, AB_2655878, AB_2655879, AB_2655880, AB_2655881, AB_2655882, AB_2655883

References for CD193 (CCR3) Antibody, anti-mouse, REAfinity™

Publications

  1. Tachimoto, H. et al. (2000)
    CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1
    in vitro
    .
    J. Immunol. 165: 2748 -2754.
  2. Moon, K. et al. (2007)
    Allergen-induced CD11b
    +
    CD11cint CCR3
    +
    macrophages in the lung promote eosinophilic airway inflammation in a mouse asthma model.
    Int. Immunol. 19: 1371-1381
  3. Fukuda, K. et al. (2012) The murine CCR3 receptor regulates both eosinophilia and hyperresponsiveness in IgE-mediated allergic conjunctivitis. Br. J. Ophthalmol. 96: 1132-1136

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