Clone:
REA874
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CXCR3, CXC-R3, CXCR-3, IP-10 receptor

Specifications for CD183 (CXCR3) Antibody, anti-rat, REAfinity™

Overview

Clone REA874 recognizes the rat CD183 antigen, also known as CXCR3. CD183 is a member of the CXC chemokine receptor family and is found on activated T cells, B cells, and NK cells during inflammation. CD183 plays a critical role in T cell migration and is important for activated T lymphoblast recruitment. It mediates the proliferation, survival, and angiogenic activity, and functions as a 7-transmembrane spanning receptor for the CXC chemokines CXCL9, CXCL10, and CXCL11.
Additional information: Clone REA874 displays negligible binding to Fc receptors.

Alternative names

CXCR3, CXC-R3, CXCR-3, IP-10 receptor

Detailed product information

Technical specifications

CloneREA874
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD183 (CXCR3)
Alternative names of antigenCXCR3, CXC-R3, CXCR-3, IP-10 receptor
Molecular mass of antigen [kDa]41
Distribution of antigenT cells, B cells, NK cells
Entrez Gene ID84475
RRIDAB_2726496, AB_2726567, AB_2726497, AB_2726568, AB_2726498, AB_2726565, AB_2726495, AB_2726566

References for CD183 (CXCR3) Antibody, anti-rat, REAfinity™

Publications

  1. Wang, X. et al. (2000) Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke. Mol. Pharmacol. 57(6): 1190-1198
  2. Mohan, K. et al. (2005)
    CXCR3 is required for migration to dermal inflammation by normal and
    in vivo
    activated T cells: differential requirements by CD4 and CD8 memory subsets.
    Eur. J. Immunol. 35(6): 1702-1711
  3. Sporici, R. et al. (2010) CXCR3 blockade inhibits T-cell migration into the CNS during EAE and prevents development of adoptively transferred, but not actively induced, disease. Eur. J. Immunol. 40(10): 2751-2761

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