Clone:
8F1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2bκ
Applications:
FC, MICS, IF, IHC
Alternative names:
CXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA

Specifications for CD181 (CXCR1) Antibody, anti-human

Overview

Clone 8F1 recognizes the human CD181 antigen, a multi-pass membrane protein also known as C-X-C chemokine receptor type 1 (CXCR1) or IL-8 receptor A (IL-8RA). CD181 is expressed as homodimer or heterodimer with CD182 (CXCR2) and found on granulocytes, NK cells, a subset of T lymphocytes, mast cells, monocytes, endothelial cells, megakarocytes, and oligodendrocytes. It is one of two high-affinity receptors for IL-8, a major mediator of immune and inflammatory responses implicated in many disorders, including tumor growth. IL-8, released in response to inflammatory stimuli, binds to the extracellular part of CD181. The ligand-activated intracellular signaling pathways results in neutrophil migration to the site of inflammation.

Alternative names

CXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA

Detailed product information

Technical specifications

Clone8F1
Clonalitymonoclonal
Isotypemouse IgG2bκ
Isotype controlIsotype Control Antibody, mouse IgG2b
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD181 (CXCR1)
Alternative names of antigenCXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
Molecular mass of antigen [kDa]40
Distribution of antigengranulocytes, NK cells, mast cells, monocytes, endothelial cells, megakaryocytes, oligodendrocytes
Entrez Gene ID3577
RRIDAB_2655704, AB_2655705, AB_2655706, AB_2655707, AB_2655708, AB_2655709, AB_2655710, AB_2655711, AB_2655712, AB_2655713, AB_2655714, AB_2655715, AB_2655716, AB_2655717, AB_2655718, AB_2655703

References for CD181 (CXCR1) Antibody, anti-human

Publications

  1. Cummings, C. J. et al. (1999) Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis. J. Immunol. 162(4): 2341-2346
  2. Angelis, A. A. et al. (2012) Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature 491(7426): 779-783
  3. Holmes, W. E. et al. (1991) Structure and functional expression of a human interleukin-8 receptor. Science 253(5025): 1278

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