Clone:
REA956
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
LY64, Ly78, RP105

Specifications for CD180 (RP105) Antibody, anti-human, REAfinity™

Overview

Clone REA956 recognizes the human CD180 antigen, also known as RP105, which is a 105 kDa type 1 transmembrane protein of the toll-like receptor (TLR) family. The extracellular domain of CD180 is associated with MD-1, which forms the cell surface complex RP105/MD-1. Together with TLR4, it mediates B cell recognition and signaling of LPS. RP105 is expressed on mature B cells in mantle zones as well as on monocytes, macrophages, and dendritic cells.
Additional information: Clone REA956 displays negligible binding to Fc receptors.

Alternative names

LY64, Ly78, RP105

Detailed product information

Technical specifications

CloneREA956
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
,
olive baboon (
Papio anubis
)
AntigenCD180 (RP105)
Alternative names of antigenLY64, Ly78, RP105
Molecular mass of antigen [kDa]72
Distribution of antigenB cells, dendritic cells, monocytes, macrophages, mature B cells
Entrez Gene ID4064
RRIDAB_2727263, AB_2727221, AB_2727264, AB_2727222, AB_2727268, AB_2727226, AB_2727265, AB_2727223, AB_2727266, AB_2727224, AB_2727267, AB_2727225, AB_2727262, AB_2727220

References for CD180 (RP105) Antibody, anti-human, REAfinity™

Publications

  1. Miura, Y. et al. (1998) RP105 Is associated with MD-1 and transmits an activation signal in human B cells. Blood 92: 2815 - 2822
  2. Ogata, H. et al. (2000) The toll-like receptor protein Rp105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 192: 23-30
  3. Divanovic, S. et al. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat. Immunol. 6(6): 571-578

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