Clone:
MHR73-11
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
LY64, Ly78, RP105

Specifications for CD180 (RP105) Antibody, anti-human

Overview

The monoclonal antibody MHR73-11 recognizes human CD180, also known as RP105, which is a 105 kDa type 1 transmembrane protein of the toll-like receptor (TLR) family. The extracellular domain of CD180 is associated with MD-1, which forms the cell surface complex RP105/MD-1. Together with TLR4, it mediates B cell recognition and signaling of LPS. CD180 is expressed on mature B cells in mantle zones, on monocytes, macrophages, and dendritic cells.

Alternative names

LY64, Ly78, RP105

Detailed product information

Technical specifications

CloneMHR73-11
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
,
olive baboon (
Papio anubis
)
AntigenCD180 (RP105)
Alternative names of antigenLY64, Ly78, RP105
Molecular mass of antigen [kDa]72
Distribution of antigenB cells, dendritic cells, macrophages, monocytes, plasma cells
Entrez Gene ID4064
RRIDAB_2655689, AB_2655690, AB_2655691, AB_2655692, AB_2655693, AB_2655694, AB_2655688

References for CD180 (RP105) Antibody, anti-human

Publications

  1. Miura, Y. et al. (1998) RP105 Is associated with MD-1 and transmits an activation signal in human B cells. Blood 92: 2815 - 2822
  2. Divanovic, S. et al. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat. Immunol. 6(6): 571-578
  3. Ogata, H. et al. (2000) The toll-like receptor protein Rp105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 192: 23-30

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