Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
Integrin beta-2, ITGB2, LTbetaR, TNF-R-III, Ltbr, TNFR-RP, TNFR2-RP, TNFCR, Tnfbr

Extended validation for CD18 Antibody, anti-mouse, REAfinity™


Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA1226
Cells were incubated with an excess of purified unconjugated CD18 (REA1226) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD18 Antibody, anti-mouse, REAfinity™


Clone REA1226 recognizes the murine CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an important role in leukocytes adhesion. It is expressed on all leukocytes with NK and T cells showing higher density of surface expression. The CD18 integrin complexes bind CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), iC3b, and fibrinogen. Heterodimers of CD18 with α subunits show different expression patterns on different leucocytes. Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.
Additional information: Clone REA1226 displays negligible binding to Fc receptors.

Alternative names

Integrin beta-2, ITGB2, LTbetaR, TNF-R-III, Ltbr, TNFR-RP, TNFR2-RP, TNFCR, Tnfbr

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenIntegrin beta-2, ITGB2, LTbetaR, TNF-R-III, Ltbr, TNFR-RP, TNFR2-RP, TNFCR, Tnfbr
Molecular mass of antigen [kDa]42
Distribution of antigenleukocytes
Entrez Gene ID17000
RRIDAB_2819576, AB_2819577, AB_2819578, AB_2819579, AB_2819575

Resources for CD18 Antibody, anti-mouse, REAfinity™


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References for CD18 Antibody, anti-mouse, REAfinity™


  1. Wilson, R. W. et al. (1993) Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol 151: 1571-1578
  2. Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32(3): 241-269
  3. Jakus, Z. et al. (2007) Immunoreceptor-like signaling by β 2 and β 3 integrins. Trends Cell Biol. 17(10): 493-501

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