Clone:
TS1/18
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGB2, CD18, LAD, LCAMB, LFA-1, Mac-1 α, MF17, MFI7

Specifications for CD18 Antibody, anti-human

Overview

Clone TS1/18 reacts with CD18, a type I transmembrane protein with an approximate molecular weight of 90–95 kDa. It non-covalently associates with α subunits CD11a (αL), CD11b (αM), CD11c (αX), and CD11d (αD) to form functional integrins which are expressed on leucocytes. CD18 associated integrins bind several ligands including cell surface and extracellular matrix proteins and are involved in cell-cell and cell-extracellular matrix interactions, immune regulation, and immune tolerance. Leucocytes of patients lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.

Alternative names

ITGB2, CD18, LAD, LCAMB, LFA-1, Mac-1 α, MF17, MFI7

Detailed product information

Technical specifications

CloneTS1/18
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, other
Cross-reactivityporcine
AntigenCD18
Alternative names of antigenITGB2, CD18, LAD, LCAMB, LFA-1, Mac-1 α, MF17, MFI7
Distribution of antigenleukocytes
RRIDAB_2784020, AB_2655672, AB_2655673, AB_2655674, AB_2655675, AB_2784021

References for CD18 Antibody, anti-human

Publications

  1. Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32(3): 241-269

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CD18 Antibody, anti-human

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