Clone:
HSL96
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
VPreB1, VpreB, IGI, IGVPB

Specifications for CD179a (VpreB) Antibody, anti-human

Overview

Clone HSL96 recognizes the human CD179a antigen, also known as VpreB protein, which has an incompleted Ig V domain-like structure. In association with CD179b it forms a surrogate light chain. CD179a is exclusively expressed on early pre–B cells and pro–B cells. CD179a forms a molecular complex with the Ig-mu chain on pre–B cells. It seems that this complex plays a critical role in the regulation of Ig gene rearrangements in the early steps of B cell differentiation.

Alternative names

VPreB1, VpreB, IGI, IGVPB

Detailed product information

Technical specifications

CloneHSL96
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD179a (VpreB)
Alternative names of antigenVPreB1, VpreB, IGI, IGVPB
Molecular mass of antigen [kDa]15
Distribution of antigenB cells
Entrez Gene ID7441
RRIDAB_2784018, AB_2655661, AB_2655662, AB_2655663, AB_2655664, AB_2784019

References for CD179a (VpreB) Antibody, anti-human

Publications

  1. Tsubata, T. et al. (1990) The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. J. Exp. Med. 172(3): 973-976
  2. Bankovich, A. J. et al. (2007) Structural insight into pre-B cell receptor function. Science 316(5822): 291-294
  3. Guelpa-Fonlupt, V. et al. (1994) The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. Mol. Immunol. 31(14): 1099-1108

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