Clone:
MFL3
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
hamster IgG
Applications:
FA, FC
Alternative names:
FasL, APT1LG1, CD95L, TNFSF6, gld

Specifications for CD178 Antibody, anti-mouse

Overview

The monoclonal antibody MFL3 recognizes the type II transmembrane glycoprotein mouse CD178, also known as Fas Ligand (FasL) or CD95 Ligand (CD95L), which is a 40 kDa member of the TNF cytokine family expressed on activated lymphocytes such as T cells, NK cells, or monocytes as well as in immune-privilaged sites, e.g cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules.

Alternative names

FasL, APT1LG1, CD95L, TNFSF6, gld

Detailed product information

Technical specifications

CloneMFL3
Clonalitymonoclonal
Isotypehamster IgG
Hosthamster
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD178
Alternative names of antigenFasL, APT1LG1, CD95L, TNFSF6, gld
Distribution of antigenT cells, monocytes, NK cells
RRIDAB_2655651, AB_2655652, AB_2655653, AB_2655654, AB_2655655, AB_2655656, AB_2655657, AB_2655658, AB_2661340

References for CD178 Antibody, anti-mouse

Publications

  1. Oyaizu, N. et al. (1997)
    Monocytes express Fas ligand upon CD4 cross-linking and induce CD4
    +
    T cells apoptosis: a possible mechanism of bystander cell death in HIV infection.
    J. Immunol. 158: 2456 -2463
  2. Kayagaki, N. et al. (1997) Polymorphism of murine Fas ligand that affects the biological activity. Proc. Natl. Acad. Sci. U.S.A. 94: 3914 -3919
  3. Takahashi, T. et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76(6): 969-976
  4. Janssen, O. et al. (2003) CD95 ligand – death factor and costimulatory molecule? Cell Death Differ. 10(11): 1215-1225

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