Clone:
REA1056
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
FASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6

Specifications for CD178 Antibody, anti-human, REAfinity™

Overview

Clone REA1056 recognizes the CD178 antigen, a type II transmembrane glycoprotein also known as Fas ligand or CD95L. It is expressed on activated lymphocytes, e.g., T cells, NK cells, monocytes, or granulocytes, as well as at immune-privileged sites, e.g., cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane-bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules.
Additional information: Clone REA1056 displays negligible binding to Fc receptors.

Alternative names

FASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6

Detailed product information

Technical specifications

CloneREA1056
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD178
Alternative names of antigenFASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6
Molecular mass of antigen [kDa]31
Distribution of antigendendritic cells, endothelial cells, epithelial cells, granulocytes, lymphocytes, monocytes, NK cells, T cells, thymocytes
Entrez Gene ID356
RRIDAB_2733775, AB_2733776, AB_2733347, AB_2733348, AB_2732962, AB_2732963, AB_2734006, AB_2734007

References for CD178 Antibody, anti-human, REAfinity™

Publications

  1. Suda, T. et al. (1993) Molecular cloning and expression of human Fas ligand. Cell 75: 1169-1178
  2. Kayagaki, N. et al. (1995) Metalloproteinase-mediated release of human Fas ligand. J. Exp. Med. 182: 1777-1783
  3. Janssen, O. et al. (2003) CD95 ligand – death factor and costimulatory molecule? Cell Death Differ. 10: 1215-1225